4-Fluorobenzoyl chloride → 1-(4-t-Butylbenzyl)-4-(4-fluorobenzoylamino)-5-imidazolecarboxamide

HRID 382416

Reaktionsgleichung

Reaktionsgleichung von HRID 382416
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:21][C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=1>>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:26](=[O:27])[C:25]3[CH:29]=[CH:30][C:22]([F:21])=[CH:23][CH:24]=3)[N:3]=[CH:4]2)=[CH:12][CH:13]=1)([CH3:20])([CH3:19])[CH3:18]

Komponenten

3

Edukt 2

HCID 678794-Fluorobenzoyl chlorideHCID 183602894-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide

Produkt 1

HCID 183603641-(4-t-Butylbenzyl)-4-(4-fluorobenzoylamino)-5-imidazolecarboxamideAusbeute 56 %

Versuchsvorschrift

An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 2.63 g (9.66 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 57 and 4-fluorobenzoyl Chloride instead of benzoyl chloride to obtain 2.13 g of 1-(4-t-butylbenzyl)-4-(4-fluorobenzoylamino)-5-imidazolecarboxamide (yield 56%).

Aufarbeitung

  1. customAn amidation reaction

Quellen und Nachweise

ORD-Eintrag
ord-f381f676ce77489f895b5e0d57d77d03
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310070B1

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