4-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide → 1-(4-t-butylbenzyl)-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazolecarboxamide

Beteiligte Stoffe

Reaktionsschritte

An amidation reaction and post-treatment were carried out under the same conditions as in Example 17, using 4.31 g (14.0 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide which was prepared in the same manner as in Example 57 and 3-(N-t-butyloxycarbonyl-N-methylamino)benzoic acid instead of 3-pyridylacetic acid hydrochloride to obtain 4.59 g of 1-(4-t-butylbenzyl)-4-(3-(N-t-butyloxycarbonyl-N-methylamino)benzoylamino)-5-imidazolecarboxamide (yield 65%).

Herkunft & Nachweise