HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → (E)-1-(4-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | 2-(2-Phenylethenyl)-1h-benzimidazole | HCID 242965 | — |
| Edukt | 2-Fluoro-4-methylpyridine | HCID 2737403 | — |
| Edukt | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | (E)-1-(4-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride | HCID 22736699 | — |
Reaktionsschritte
Free base of the titled compound was prepared from 2-styryl-1H-benzimidazole and 2-fluoro-4-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06310079B1 |
| Quelldatensatz | uspto-grants-2001_10 |
| ORD ID | ord-b6bc70bd70dd453893ec6ad11ec32443 |
| Quellennotiz | uspto-grants-2001_10 |