Oxalic Acid → (E)-5-Ethoxy1-1-(2-pyridyl)-2-styryl-1H-benzimidazole oxalate

HRID 382564

Reaktionsgleichung

Reaktionsgleichung von HRID 382564
[CH2:1]([O:3]C1C=CC(N)=C([N+]([O-])=O)C=1)[CH3:2].[N:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]1[C:24]2[CH:25]=[CH:26][C:27](C(F)(F)F)=[CH:28][C:23]=2[N:22]=[C:21]1/[CH:33]=[CH:34]/[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1.[C:41]([OH:46])(=[O:45])[C:42]([OH:44])=[O:43]>C(OCC)(=O)C>[C:41]([OH:46])(=[O:45])[C:42]([OH:44])=[O:43].[O:3]([C:27]1[CH:26]=[CH:25][C:24]2[N:20]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][N:14]=3)[C:21](/[CH:33]=[CH:34]/[C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[N:22][C:23]=2[CH:28]=1)[CH2:1][CH3:2]

Komponenten

5

Edukt 3

HCID 971Oxalic AcidHCID 692294-Ethoxy-2-nitroanilineHCID 22736704(E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole

Produkt 1

HCID 22736673(E)-5-Ethoxy1-1-(2-pyridyl)-2-styryl-1H-benzimidazole oxalate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Free base of the titled compound was prepared from 4-ethoxy-2-nitroaniline according to the preparation of (E)-1-(2-pyridyl)-2-styryl-5-trifluoromethyl-1H-benzimidazole (Example 57). The free base and oxalic acid were dissolved into ethyl acetate. Concentration and recrystallization from ethyl acetate/n-hexane yielded the titled compound.

Aufarbeitung

  1. concentrationConcentration and recrystallization from ethyl acetate/n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-0413da1713464f24b991163386a73d3f
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310079B1

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