HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → (E)-5-Methyl-2-(4-methoxystyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | 4-Methyl-2-nitroaniline | HCID 6978 | — |
| Edukt | (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole | HCID 9796241 | — |
| Edukt | trans-4-Methoxycinnamoyl chloride | HCID 10976422 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | (E)-5-Methyl-2-(4-methoxystyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride | HCID 18360812 | — |
Reaktionsschritte
Free base of the titled compound was prepared from 4-methyl-2-nitroaniline and (E)-4-methoxycinnamoyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06310079B1 |
| Quelldatensatz | uspto-grants-2001_10 |
| ORD ID | ord-1b3ce5fe73c64cc1b630a5b48c7e592d |
| Quellennotiz | uspto-grants-2001_10 |