Methyl iodide → HCID 178422144, Verbindung

HRID 382621Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 382621
[OH:1][C@@H:2]([C@H:4]1[C:33](=[O:34])[N:6]2[C:7]([C:20]([O:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][CH:25]=3)=[O:21])=[C:8]([C:11]3[S:15][C:14]4=[CH:16][N:17]=[CH:18][N:13]4[C:12]=3[CH3:19])[C@H:9]([CH3:10])[C@H:5]12)[CH3:3].[I:35][CH3:36]>ClCCl>[I-:35].[CH3:19][C:12]1[N+:13]2[C:14](=[CH:16][N:17]([CH3:36])[CH:18]=2)[S:15][C:11]=1[C:8]1[C@H:9]([CH3:10])[C@@H:5]2[C@@H:4]([C@H:2]([OH:1])[CH3:3])[C:33](=[O:34])[N:6]2[C:7]=1[C:20]([O:22][CH2:23][C:24]1[CH:25]=[CH:26][C:27]([N+:30]([O-:32])=[O:31])=[CH:28][CH:29]=1)=[O:21]

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 120700444-Nitrobenzyl (1S,5R,6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-(3-methylimidazo[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate

Produkt 1

HCID 178422144HCID 178422144, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 73.6 mg of 4-nitrobenzyl (1S,5R, 6S)-6-((1R)-1-hydroxyethyl)-1-methyl-2-(3-methylimidazo[5,1-b]thiazol-2-yl)-1-carbapen-2-em-3-carboxylate in 0.5 ml of dry dichloromethane was added 0.95 ml of iodomethane, and the mixture was stirred under the atmosphere of argon in the darkness at room temperature for 18 hours. Unreacted reagent was removed under reduced pressure to give 89.1 mg of 4-nitrobenzyl (1S,5R,6S)-2-(3,6-dimethylimidazo[5,1-b]thiazolium-2-yl)-6-((1R)-1-hydroxyethyl)-1-methyl-1-carbapen-2-em-3-carboxylate iodide.

Aufarbeitung

  1. customwas removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ccfb4c2ea0a040f58e7cca3712df7a7d
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310056B1

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