(1-Methyl-1H-1,2,4-triazol-3-yl)methanol → 3-(3-Methylisoxazol-5-yl)-6-(1-methyl-1,2,4-triazol-3-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

HRID 382946Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 382946
[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[N:11]3[N:12]=[C:13]([O:20][CH2:21][C:22]4C=CC=[CH:24][N:23]=4)[C:14]4[C:19]([C:10]3=[N:9][N:8]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[O:4][N:3]=1.OC[C:30]1N=C[N:32](C)[N:31]=1>>[CH3:1][C:2]1[CH:6]=[C:5]([C:7]2[N:11]3[N:12]=[C:13]([O:20][CH2:21][C:22]4[N:23]=[CH:24][N:31]([CH3:30])[N:32]=4)[C:14]4[C:19]([C:10]3=[N:9][N:8]=2)=[CH:18][CH:17]=[CH:16][CH:15]=4)[O:4][N:3]=1

Komponenten

3

Edukt 2

HCID 10351670(1-Methyl-1H-1,2,4-triazol-3-yl)methanolHCID 183618903-(3-Methylisoxazol-5-yl)-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

Produkt 1

HCID 183618823-(3-Methylisoxazol-5-yl)-6-(1-methyl-1,2,4-triazol-3-yl)methyloxy-1,2,4-triazolo[3,4-a]phthalazine

Versuchsvorschrift

The title-compound was prepared from the product of Example 120 part a and 3-hydroxymethyl-1-methyl-1,2,4-triazole (prepared using the conditions of Itoh and Okongi, EP-A-421210) following the conditions described for Example 71, mp 270-271.5° C.; 1H NMR (360 MHz, CDCl3) δ 2.50 (3H, s, CH3), 3.97 (3H, s, CH3), 5.73 (2H, s, CH2), 7.31 (1H, s, Ar—H), 7.82 (1H, m, Ar—H), 7.97 (1H, m, Ar—H), 8.09 (1H, s, Ar—H), 8.31 (1H, d, J=8.6 Hz, Ar—H), 8.70 (1H, d, J=8.6 Hz, Ar—H); MS (ES+) m/e 363 [MH]+; Anal. Found. C, 55.92; H, 3.63; N, 30.16. C17H4N8O2. 0.06CH2Cl2 requires C, 55.77; H, 3.87, N, 30.49%.

Aufarbeitung

  1. customprepared

Quellen und Nachweise

ORD-Eintrag
ord-c7b860a01a4241128d784a347433bfa4
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310203B1

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