HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Acetoxypropionyl Chloride → 5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Acetoxypropionyl Chloride | HCID 4547492 | — |
| Edukt | 3-Acetoxymethyl-5-(2,3-diacetoxypropylaminocarbonyl)-2,4,6-triiodoaniline | HCID 18429130 | — |
| Lösungsmittel | Dimethylacetamide | HCID 31374 | — |
| Produkt | 5-(2-Acetoxypropionylamino)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide | HCID 18429188 | 100% |
Reaktionsschritte
5-Amino-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide (3.20 g, 4.3 mmol) was dissolved in dry dimethylacetamide (4 ml). 2-Acetoxypropionyl chloride (2.17 ml, 17.2 mmol) was then added dropwise with efficient stirring. Stirring was continued over night. After work up according to the procedure in Example 24i, 3.66 g (100%) of product was isolated.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06310243B1 |
| Quelldatensatz | uspto-grants-2001_10 |
| ORD ID | ord-1d2e02de960d42468d097c0e4628acfe |
| Quellennotiz | uspto-grants-2001_10 |