Ethyl{3-[3-(4-cyanophenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate → Ethyl{3-[3-(4-aminomethylphenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

HRID 383636Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 383636
[CH2:1]([O:3][C:4](=[O:28])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[CH:25]=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=3)=[N:14]2)[CH:7]=1)[CH3:2]>N.[Ni]>[CH2:1]([O:3][C:4](=[O:28])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][N:13]2[C:18](=[O:19])[CH:17]=[CH:16][C:15]([C:20]3[CH:21]=[CH:22][C:23]([CH2:26][NH2:27])=[CH:24][CH:25]=3)=[N:14]2)[CH:7]=1)[CH3:2]

Komponenten

4

Edukt 1

HCID 59406745Ethyl{3-[3-(4-cyanophenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

Produkt 1

HCID 59406699Ethyl{3-[3-(4-aminomethylphenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 222AmmoniaLösungsmittel

Versuchsvorschrift

26 mmol of ethyl{3-[6-oxo-3-(4-cyanophenyl)-6H-pyridazin-1-ylmethyl]-phenyl}carbamate are dissolved in 300 ml of methanolic ammonia solution (10%), 4 g of Raney Ni are added, and the mixture is hydrogenated at room temperature for 16 h under a hydrogen atmosphere (5 bar). The catalyst is separated off, rinsed with methanol, and the filtrate is evaporated.

Aufarbeitung

  1. customThe catalyst is separated off
  2. washrinsed with methanol
  3. customthe filtrate is evaporated

Quellen und Nachweise

ORD-Eintrag
ord-462b1582d16c4c04a98219049b4e765f
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367668B2

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