Water → Ethyl[3-(6-oxo-3-thiocarbamoyl-6h-pyridazin-1-yl-methyl)phenyl]carbamate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

200 mg (0.67 mmol) of ethyl[3-(3-cyano-6-oxo-6H-pyridazin-1-ylmethyl)-phenyl]carbamate are dissolved in 1 ml of DMF, and 219 mg (2 mmol) of diethylammonium chloride and 165 mg (2 mmol) of sodium sulfide hydrate are added. The yellow suspension is stirred at 55° C. for 2 hours. 10 ml of water are added to the reaction mixture. The precipitate is filtered off with suction, washed with water and dried in vacuo. The substance is reacted further without further purification.

Herkunft & Nachweise