Ethyl isocyanate → HCID 57329705, Verbindung

HRID 38367Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 38367
[NH2:1][C:2]1[C:3]([O:20][CH3:21])=[CH:4][C:5]([CH:17]([CH3:19])[CH3:18])=[C:6]([CH:16]=1)[O:7][C:8]1[C:9]([NH2:15])=[N:10][C:11]([NH2:14])=[N:12][CH:13]=1.[CH2:22]([N:24]=[C:25]=[O:26])[CH3:23]>C1(C)C=CC=CC=1>[NH2:14][C:11]1[N:10]=[C:9]([NH2:15])[C:8]([O:7][C:6]2[C:5]([CH:17]([CH3:19])[CH3:18])=[CH:4][C:3]([O:20][CH3:21])=[C:2]([NH:1][C:25]([NH:24][CH2:22][CH3:23])=[O:26])[CH:16]=2)=[CH:13][N:12]=1

Komponenten

4

Edukt 2

HCID 8022Ethyl isocyanateHCID 595985735-(5-Amino-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine

Produkt 1

HCID 57329705HCID 57329705, VerbindungAusbeute 83,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 5-(5-amino-2-Isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine (0.117 g, 0.4 mmol) and ethyl isocyanate (0.034 g, 0.5 mmol) in 4 mL of toluene was heated to 100° C. in a sealed tube. After 5 h the solution was cooled and concentrated in vacuo gave a brown solid. Purification via flash chromatography (CH2Cl2/MeOH 97:3) afforded 1-[5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-phenyl]-3-ethyl-urea (0.120 g, 83%) as a white solid; (M+H)=361.

Aufarbeitung

  1. temperatureAfter 5 h the solution was cooled
  2. concentrationconcentrated in vacuo
  3. customgave a brown solid
  4. customPurification via flash chromatography (CH2Cl2/MeOH 97:3)

Quellen und Nachweise

ORD-Eintrag
ord-193b8a812bb14df7b9ba8859cdf4609a
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524725B2

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