Hydrochloric Acid → 1-Azabicyclo[2.2.1]heptan-3-ol hydrochloride

HRID 383945Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 383945
[N:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[C:3](=[O:8])[CH2:2]2.[ClH:9]>[Pt]=O.CCO>[ClH:9].[N:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([OH:8])[CH2:2]2

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 108554071-Azabicyclo[2.2.1]heptan-3-one

Produkt 1

HCID 685941551-Azabicyclo[2.2.1]heptan-3-ol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 82844Platinum oxide (PtO)KatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1-azabicyclo[2.2.1]heptan-3-one (Journal of Medicinal Chemistry, 1990, 33, pp. 2690-2697), hydrochloride (350 mg), platinum oxide (35 mg), and EtOH (5 mL) was stirred at room temperature under a hydrogen atmosphere. The reaction mixture was filtered through Celite, and the filtrate was concentrated under reduced pressure to obtain 1-azabicyclo[2.2.1]heptan-3-ol hydrochloride as a pale brown solid.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-91301bffe9f34608abe4a4981fa409e6
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367696B2

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