HCID 86641942, Verbindung → HCID 67272423, Verbindung

HRID 384119Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 384119
Cl[C:2]1[N:7]=[C:6]([CH2:8][OH:9])[C:5]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1>C(O)C.[C].[Pd]>[O:10]([C:5]1[C:6]([CH2:8][OH:9])=[N:7][CH:2]=[CH:3][CH:4]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Komponenten

4

Edukt 1

HCID 86641942HCID 86641942, Verbindung

Produkt 1

HCID 67272423HCID 67272423, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of (6-chloro-3-phenoxypyridin-2-yl)methanol (88 mg) in ethanol (1.5 ml), 10 mg of 10% palladium-carbon catalyst was added, and the reaction solution was stirred for 20 hours under hydrogen atmosphere. The catalyst was filtered off through Celite, and the filtrate was distilled off under reduced pressure to afford the title compound as a yellow solid.

Aufarbeitung

  1. filtrationThe catalyst was filtered off through Celite
  2. distillationthe filtrate was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bd62ea0b8b5c446fa104de0383a94650
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367708B2

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