4-Methoxycarbonylphenylboronic acid → Methyl 3-(1-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}-1H-indol-4-yl)benzoate

HRID 38467

Reaktionsgleichung

Reaktionsgleichung von HRID 38467
FC(F)(F)S(O[C:7]1[CH:15]=[C:14]([C:16]([N:18]2[CH2:23][CH2:22][C:21]3([CH2:32][C:31](=[O:33])[C:30]4[C:25](=[CH:26][CH:27]=[C:28]([C:34]5[CH:35]=[N:36][N:37]([CH3:39])[CH:38]=5)[CH:29]=4)[O:24]3)[CH2:20][CH2:19]2)=[O:17])[CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][N:11]2[CH:40]1[CH2:42][CH2:41]1)(=O)=O.[CH3:45][O:46][C:47]([C:49]1[CH:50]=[C:51](B(O)O)[CH:52]=[CH:53][CH:54]=1)=[O:48].COC(C1C=CC(B(O)O)=CC=1)=O>>[CH:40]1([N:11]2[C:12]3[C:8](=[C:7]([C:51]4[CH:50]=[C:49]([CH:54]=[CH:53][CH:52]=4)[C:47]([O:46][CH3:45])=[O:48])[CH:15]=[C:14]([C:16]([N:18]4[CH2:23][CH2:22][C:21]5([CH2:32][C:31](=[O:33])[C:30]6[C:25](=[CH:26][CH:27]=[C:28]([C:34]7[CH:35]=[N:36][N:37]([CH3:39])[CH:38]=7)[CH:29]=6)[O:24]5)[CH2:20][CH2:19]4)=[O:17])[CH:13]=3)[CH:9]=[CH:10]2)[CH2:41][CH2:42]1

Komponenten

4

Edukt 3

HCID 27343694-Methoxycarbonylphenylboronic acidHCID 27347143-(Methoxycarbonyl)benzeneboronic acidHCID 582087121-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}-1H-indol-4-yl trifluoromethanesulfonate

Produkt 1

HCID 58208671Methyl 3-(1-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}-1H-indol-4-yl)benzoate

Versuchsvorschrift

The intended compound was produced according to the procedure described in Example 28-1 but using 1-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4′-piperidin]-1′-yl]carbonyl}-1H-indol-4-yl trifluoromethanesulfonate and [3-(methoxycarbonyl)phenyl]boronic acid in place of 8-cyclopropyl-2-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4′-piperidin]-1′-yl]carbonyl}quinolin-4-yl trifluoromethanesulfonate and [4-(methoxycarbonyl)phenyl]boronic acid.

Aufarbeitung

  1. customThe intended compound was produced

Quellen und Nachweise

ORD-Eintrag
ord-aaeeccadf5634b4ea737260ae2686402
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524730B2

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