5-Amino-3-chloropyrazine-2-carbonitrile → 5-Amino-3-methoxypyrazine-2-carbonitrile

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

5-Amino-3-chloropyrazine-2-carbonitrile (52 mg, 0.34 mmol) was suspended in NaOMe/MeOH (2M, 2 mL). The reaction mixture was heated at 80° C. for 30 min using microwave irradiation. After cooling, the mixture was diluted with MeOH (3 mL) and water (2 mL). The solvents were concentrated and the resulting precipitate was filtered off, washed with water (3 mL) and dried in vacuo to give the title compound as a yellow solid (33 mg, 58%).

Herkunft & Nachweise