Hydrochloric Acid → 5-{4-Oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinamide dihydrochloride

HRID 38475

Reaktionsgleichung

Reaktionsgleichung von HRID 38475
C(OC([N:8]1[CH2:13][CH2:12][C:11]2([CH2:22][C:21](=[O:23])[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:24]4[CH:25]=[N:26][CH:27]=[C:28]([CH:32]=4)[C:29]([NH2:31])=[O:30])[CH:19]=3)[O:14]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:33]>O1CCOCC1>[ClH:33].[ClH:33].[O:23]=[C:21]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([C:24]3[CH:25]=[N:26][CH:27]=[C:28]([CH:32]=3)[C:29]([NH2:31])=[O:30])[CH:19]=2)[O:14][C:11]2([CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH2:22]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 579310025-{1'-tert-Butoxycarbonyl-4-oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinamide

Produkt 1

HCID 667820395-{4-Oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinamide dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

5-{1′-tert-butoxycarbonyl-4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinamide (1.30 g) was suspended in dioxane (10 ml) and 4N HCl in dioxane (20 ml) was added thereto, and stirred at room temperature for 18 h. The resulted precipitate was filtered, washed with dioxane and Et2O to obtain the intended compound as a colorless solid.

Aufarbeitung

  1. filtrationThe resulted precipitate was filtered
  2. washwashed with dioxane and Et2O

Quellen und Nachweise

ORD-Eintrag
ord-1fa9396ccade412b86164f9adbce59fa
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524730B2

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