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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 384912Erstellt: 26. Oktober 2026

3-(4-Bromo-2-methyl-phenyl)-5-fluoro-pyridine → Rac-[1-(3,4-dichloro-phenyl)-2-[4-(5-fluoro-pyridin-3-yl)-3-methyl-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/384912

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt3-(4-Bromo-2-methyl-phenyl)-5-fluoro-pyridineHCID 68409948—
EduktRac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl esterHCID 87442373—
ProduktRac-[1-(3,4-dichloro-phenyl)-2-[4-(5-fluoro-pyridin-3-yl)-3-methyl-phenyl]-2-oxo-ethyl]-carbamic acid tert-butyl esterHCID 68408672—

Reaktionsschritte

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 3-(4-bromo-2-methyl-phenyl)-5-fluoro-pyridine (Intermediate 12) in analogy to Example 1a): MS (ISP): 489.2 and 491.1 (M+H)+.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08367838B2
Quelldatensatzuspto-grants-2013_02
ORD IDord-66efa25ca539409cbe14d2d9df339209
Quellennotizuspto-grants-2013_02