5-Bromo-3-methyl-2-(oxan-4-yloxy)pyridine → Rac-[1-(3,4-dichloro-phenyl)-2-[5-methyl-6-(tetrahydro-pyran-4-yloxy)-pyridin-3-yl]-2-oxo-ethyl]-carbamic acid tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[CH:26]=[C:27]([CH3:38])[C:28]([O:31][CH:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)=[N:29][CH:30]=1>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9]([C:25]1[CH:30]=[N:29][C:28]([O:31][CH:32]2[CH2:33][CH2:34][O:35][CH2:36][CH2:37]2)=[C:27]([CH3:38])[CH:26]=1)=[O:14])([CH3:2])([CH3:3])[CH3:4]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 5-bromo-3-methyl-2-(tetrahydro-pyran-4-yloxy)-pyridine (Intermediate 24) in analogy to Example 1a): MS (ISN): 493.1 and 495.2 (M−H)−.