4-(4-Bromo-3-fluoro-phenoxy)-tetrahydro-pyran → HCID 68409793, Verbindung

HRID 384929

Reaktionsgleichung

Reaktionsgleichung von HRID 384929
[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9](=[O:14])N(OC)C)([CH3:4])([CH3:3])[CH3:2].Br[C:25]1[CH:37]=[CH:36][C:28]([O:29][CH:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[CH:27][C:26]=1[F:38]>>[C:1]([O:5][C:6](=[O:23])[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[C:17]([Cl:22])[CH:16]=1)[C:9]([C:25]1[CH:37]=[CH:36][C:28]([O:29][CH:30]2[CH2:35][CH2:34][O:33][CH2:32][CH2:31]2)=[CH:27][C:26]=1[F:38])=[O:14])([CH3:2])([CH3:3])[CH3:4]

Komponenten

3

Edukt 2

HCID 652029954-(4-Bromo-3-fluoro-phenoxy)-tetrahydro-pyran2×HCID 87442373Rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester2×

Produkt 1

HCID 68409793HCID 68409793, Verbindung

Versuchsvorschrift

The title compound was prepared from rac-[(3,4-dichloro-phenyl)-(methoxy-methyl-carbamoyl)-methyl]-carbamic acid tert-butyl ester (Intermediate 9) and 4-(4-bromo-3-fluoro-phenoxy)-tetrahydro-pyran (Intermediate 31) in analogy to Example 1a): MS (ISP): 498.1 and 500.2 (M+H)+, 442.2 and 444.0 ((M-isobutene)+H)+ (100%).

Quellen und Nachweise

ORD-Eintrag
ord-757f02853d85431fa96f247cc12d7717
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367838B2

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