HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-(3-fluorobenzyl)-5-nitro-1H-indazole → 1-(3-Fluorobenzyl)-1H-indazol-5-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-(3-fluorobenzyl)-5-nitro-1H-indazole | HCID 21966490 | — |
| Katalysator | Palladium | HCID 23938 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | 1-(3-Fluorobenzyl)-1H-indazol-5-amine | HCID 7147073 | 64,5% |
Reaktionsschritte
1-(3-Fluorobenzyl)-5-nitro-1H-indazole from Example 7A (500 mg) was dissolved in ethanol (40 mL) and was hydrogenated in an H-Cube™ (room temperature, 1 bar, 1 mL/min, 10% Pd/C catalyst). After removal of the solvent and trituration with tert-butyl methyl ether, 287 mg (64%) of the title compound were obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08524722B2 |
| Quelldatensatz | uspto-grants-2013_09 |
| ORD ID | ord-f7559777ac2d4ab590349e2063f27828 |
| Quellennotiz | uspto-grants-2013_09 |