Toluene → 3-Cyano-4-methoxy-5-trifluoromethoxybenzoyl chloride

HRID 385145Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385145
[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:14][C:15]([F:18])([F:17])[F:16])[C:11]=1[O:12][CH3:13])[C:6](O)=[O:7])#[N:2].C1(C)C=CC=CC=1.S(Cl)([Cl:28])=O>CN(C)C=O>[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:14][C:15]([F:18])([F:17])[F:16])[C:11]=1[O:12][CH3:13])[C:6]([Cl:28])=[O:7])#[N:2]

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 24386Thionyl ChlorideHCID 681091153-Cyano-4-methoxy-5-trifluoromethoxybenzoic acid

Produkt 1

HCID 866681833-Cyano-4-methoxy-5-trifluoromethoxybenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To 3-cyano-4-methoxy-5-trifluoromethoxybenzoic acid (500 mg), toluene (10 mL), N,N-dimethylformamide (3 droplets) and thionyl chloride (0.28 mL) were added, and then the mixture was stirred at 60° C. for 6 hours. The solvent was distilled off under reduced pressure and the obtained residue was azeotroped with toluene and used for the synthesis of (i).

Aufarbeitung

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe obtained residue was azeotroped with toluene
  3. customused for the synthesis of (i)

Quellen und Nachweise

ORD-Eintrag
ord-2da99fd23d9a4913a70de0d32358d53b
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367843B2

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