8-Bromo-N-[[1,6-diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]octanamide → (R)-8-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]-N-[[1,6-diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]octanamide

HRID 385279Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385279
[Si:1]([O:8][C@H:9]([C:30]1[CH:39]=[CH:38][C:37]([OH:40])=[C:36]2[C:31]=1[CH:32]=[CH:33][C:34](=[O:41])[NH:35]2)[CH2:10][NH:11][CH2:12][CH2:13]CC#CC1C=CC(NC(=O)C(F)(F)F)=CC=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].BrCC[CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][C:50]([NH:52][CH2:53][C:54]1[C:55]([NH:67][CH:68]2[CH2:73][CH2:72][O:71][CH2:70][CH2:69]2)=[C:56]2[CH:64]=[N:63][N:62]([CH2:65][CH3:66])[C:57]2=[N:58][C:59]=1[CH2:60][CH3:61])=[O:51]>>[Si:1]([O:8][C@H:9]([C:30]1[CH:39]=[CH:38][C:37]([OH:40])=[C:36]2[C:31]=1[CH:32]=[CH:33][C:34](=[O:41])[NH:35]2)[CH2:10][NH:11][CH2:12][CH2:13][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][C:50]([NH:52][CH2:53][C:54]1[C:55]([NH:67][CH:68]2[CH2:69][CH2:70][O:71][CH2:72][CH2:73]2)=[C:56]2[CH:64]=[N:63][N:62]([CH2:65][CH3:66])[C:57]2=[N:58][C:59]=1[CH2:60][CH3:61])=[O:51])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 580173008-Bromo-N-[[1,6-diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]octanamideHCID 58505275(R)-N-(4-(5-((2-((tert-butyldimethylsilyl)oxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)pent-1-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Produkt 1

HCID 66990001(R)-8-[[2-[(tert-Butyldimethylsilyl)oxy]-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]-N-[[1,6-diethyl-4-[(tetrahydro-2H-pyran-4-yl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl]methyl]octanamide

Versuchsvorschrift

The title compound was prepared in a manner analogous to that described for Intermediate 37, using Intermediate 33 in place of Intermediate 26. ES/MS calcd. for C41H64N7O5Si 762.5. found m/z=762.5 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-082bf0a2189a44a5bf93e1c7743a73e0
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367829B2

Notizen zur Reaktion

Wird geladen…