2,3-Diamino-6-methoxypyridine dihydrochloride → 2-(2-Dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

HRID 3853Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 3853
[CH3:1][N:2]([CH3:15])[C:3]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.Cl.Cl.[NH2:18][C:19]1[C:24]([NH2:25])=[CH:23][CH:22]=[C:21]([O:26][CH3:27])[N:20]=1>P(Cl)(Cl)(Cl)=O>[CH3:1][N:2]([CH3:15])[C:3]1[CH:11]=[C:10]([N+:12]([O-:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[NH:25][C:24]2[C:19]([N:18]=1)=[N:20][C:21]([O:26][CH3:27])=[CH:22][CH:23]=2

Komponenten

4

Edukt 2

HCID 30239192,3-Diamino-6-methoxypyridine dihydrochlorideHCID 201382202-(Dimethylamino)-4-nitrobenzoic acid

Produkt 1

HCID 135323492-(2-Dimethylamino-4-nitro-phenyl)-5-methoxy-imidazo[4,5-b]pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 24813Phosphorus oxychlorideLösungsmittel

Versuchsvorschrift

An amount of 0.45 gm of 2-dimethylamino-4-nitro-benzoic acid is suspended in 15 ml of phosphorus oxychloride, and 0.45 gm of 2,3-diamino-6-methoxy-pyridine dihydrochloride are added. The mixture is refluxed for two hours and after cooling poured onto water. The aqueous solution is made ammoniacal with cooling, and the product precipitated is treated as in Example 4(b).

Aufarbeitung

  1. temperatureThe mixture is refluxed for two hours
  2. temperatureafter cooling
  3. additionpoured onto water
  4. temperaturewith cooling
  5. customthe product precipitated
  6. additionis treated as in Example 4(b)

Quellen und Nachweise

ORD-Eintrag
ord-2a7e3c04034f4962805f2b8605f567fe
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04722929

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