1-(3-Fluorobenzyl)-1H-indazol-5-amine → N-[1-(3-Fluorobenzyl)-1H-indazol-5-yl]-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-c]-azepin-4-amine

HRID 38564

Reaktionsgleichung

Reaktionsgleichung von HRID 38564
Cl[C:2]1[C:7]2[C:8]3[CH2:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][C:9]=3[S:22][C:6]=2[N:5]=[CH:4][N:3]=1.[F:23][C:24]1[CH:25]=[C:26]([CH:38]=[CH:39][CH:40]=1)[CH2:27][N:28]1[C:36]2[C:31](=[CH:32][C:33]([NH2:37])=[CH:34][CH:35]=2)[CH:30]=[N:29]1>>[F:23][C:24]1[CH:25]=[C:26]([CH:38]=[CH:39][CH:40]=1)[CH2:27][N:28]1[C:36]2[C:31](=[CH:32][C:33]([NH:37][C:2]3[C:7]4[C:8]5[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][C:9]=5[S:22][C:6]=4[N:5]=[CH:4][N:3]=3)=[CH:34][CH:35]=2)[CH:30]=[N:29]1

Komponenten

3

Edukt 2

HCID 71470731-(3-Fluorobenzyl)-1H-indazol-5-amineHCID 58116846tert-Butyl 4-chloro-5,6,7,9-tetrahydro-8H-pyrimido[5',4':4,5]thieno[2,3-c]azepine-8-carboxylate

Produkt 1

HCID 58116853N-[1-(3-Fluorobenzyl)-1H-indazol-5-yl]-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-c]-azepin-4-amineAusbeute 63 %

Versuchsvorschrift

The title compound was synthesized in analogy to Example 12A from tert-butyl 4-chloro-5,6,7,9-tetrahydro-8H-pyrimido[5′,4′:4,5]thieno[2,3-c]azepine-8-carboxylate from Example 80A (200 mg, 0.59 mmol) and 1-(3-fluorobenzyl)-1H-indazol-5-amine from Example 8A (149 mg, 0.62 mmol) to yield 213 mg (77% purity, 63% yield), which was used without further purification.

Aufarbeitung

  1. customto yield 213 mg (77% purity, 63% yield), which
  2. customwas used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-3dc9163b83654845a25b1927139dafbf
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524722B2

Verknüpfte Notizen

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