5-[6-(1-Hydroxy-1-methylethyl)pyridin-3-yl]-2-nitrothiophene-3-carboxamide → 2-Amino-5-[6-(1-hydroxy-1-methylethyl)pyridin-3-yl]thiophene-3-carboxamide
Reaktionsgleichung
[OH:1][C:2]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[S:15][C:14]([N+:16]([O-])=O)=[C:13]([C:19]([NH2:21])=[O:20])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])[CH3:3]>CO.[Pt]>[NH2:16][C:14]1[S:15][C:11]([C:8]2[CH:9]=[N:10][C:5]([C:2]([OH:1])([CH3:3])[CH3:4])=[CH:6][CH:7]=2)=[CH:12][C:13]=1[C:19]([NH2:21])=[O:20]Komponenten
4
Versuchsvorschrift
To 5-[6-(1-hydroxy-1-methylethyl)pyridin-3-yl]-2-nitrothiophene-3-carboxamide (245 mg, 0.80 mmol) in MeOH (20 mL) was added 3% Pt/C doped with 0.6% V (52 mg, 8.0 μmol). The reaction was stirred under a hydrogen balloon at room temperature for 4 h. The solution was diluted with MeOH, filtered through Celite, and evaporated to give the title compound as a gray solid.