2-Chloropyridine-5-boronic acid → 5-(6-Chloropyridin-3-yl)-2-nitrothiophene-3-carboxamide
Reaktionsgleichung
OC([C:5]1[N:10]=[CH:9][C:8]([C:11]2[S:15][C:14]([N+:16]([O-:18])=[O:17])=[C:13]([C:19]([NH2:21])=[O:20])[CH:12]=2)=[CH:7][CH:6]=1)(C)C.[Cl:22]C1C=CC(B(O)O)=CN=1>>[Cl:22][C:5]1[N:10]=[CH:9][C:8]([C:11]2[S:15][C:14]([N+:16]([O-:18])=[O:17])=[C:13]([C:19]([NH2:21])=[O:20])[CH:12]=2)=[CH:7][CH:6]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 5-bromo-2-nitrothiophene-3-carboxamide (Intermediate 10 Step 4) (2.0 g, 7.97 mmol) and 2-chloro-5-pyridine boronic acid (1.25 g, 7.97 mmol) according to the general procedure described in Intermediate 10 Step 5.
Quellen und Nachweise
- ORD-Eintrag
- ord-e5a2af8a8c984420bf339732100f7745
- Quelldatensatz
- uspto-grants-2013_02
- Patentnummer
- US08367706B2
Notizen zur Reaktion
Wird geladen…