Dimethylformamide dimethyl acetal → HCID 178484334, Verbindung

HRID 385741Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385741
[N+:1]([C:4]1[S:8][C:7]([C:9]([NH2:11])=[O:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>CN(C=O)C>[CH3:14][N:15](/[CH:17]=[N:11]/[C:9]([C:7]1[S:8][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)=[O:10])[CH3:16]

Komponenten

4

Edukt 2

HCID 78373Dimethylformamide dimethyl acetalHCID 3147105-Nitrothiophene-2-carboxamide

Produkt 1

HCID 178484334HCID 178484334, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

5-Nitrothiophene-2-carboxamide (5.80 g, 33.7 mmol) was combined with N,N-dimethylformamide dimethyl acetal (75 mL, 560 mmol) and stirred at 120° C. overnight (added 10 mL DMF to help dissolve the starting material). The red-brown solution was cooled to room temperature, at which point a solid precipitated from solution. The solid was isolated by filtration, washed with Et2O, and dried to provide the title compound as tan crystals.

Aufarbeitung

  1. dissolutionto help dissolve the starting material)
  2. temperatureThe red-brown solution was cooled to room temperature, at which point a solid
  3. customprecipitated from solution
  4. customThe solid was isolated by filtration
  5. washwashed with Et2O
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-78ab10ec18db451f96a7d192dfc996a2
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

Notizen zur Reaktion

Wird geladen…