Hydrazinecarboxaldehyde → 3-(4-Bromophenyl)-1H-[1,2,4]triazole
Reaktionsgleichung
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[NH:12])OCC)=[CH:4][CH:3]=1.[NH2:13][NH:14][CH:15]=O>C1(C)C(C)=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]=[CH:15][NH:14][N:13]=2)=[CH:6][CH:7]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Into a 1000 mL 3-necked flask, was placed a solution of ethyl 4-bromobenzenecarboximidoate (54.0 g, 237 mmol) in xylene (500 mL) To the mixture was added NH2NHCHO (14.22 g, 237 mmol). The resulting solution was heated to reflux overnight. The reaction mixture was cooled in an ice bath and filtered. The solid was washed with 700 mL of petroleum ether and dried in an oven under reduced pressure to afford 3-(4-bromophenyl)-1H-1,2,4-triazole (crude) as a white solid.
Aufarbeitung
- customInto a 1000 mL 3-necked flask, was placed
- temperatureThe resulting solution was heated
- temperatureto reflux overnight
- temperatureThe reaction mixture was cooled in an ice bath
- filtrationfiltered
- washThe solid was washed with 700 mL of petroleum ether
- customdried in an oven under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-a6dfce0089d44b1f9ed693d88e2046e9
- Quelldatensatz
- uspto-grants-2013_02
- Patentnummer
- US08367706B2
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