HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Oxa-3,8-diazaspiro(4.5)decan 2-one → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Oxa-3,8-diazaspiro(4.5)decan 2-one | HCID 12954114 | — |
| Edukt | 5-(2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-formyl-2-pyridinyl)amino)-3-thiophenecarboxamide | HCID 59526158 | — |
| Produkt | 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(2-oxo-1-oxa-3,8-diazaspiro[4.5]dec-8-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide | HCID 59525594 | — |
Reaktionsschritte
The title compound was prepared according to Example 106 Step 2 using 5-(2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl)-2-((6-formyl-2-pyridinyl)amino)-3-thiophenecarboxamide (19.5 mg, 0.05 mmol) and 1-oxa-3,8-diaza-spiro[4.5]decan-2-one (7.6 mg, 0.05 mmol) as the starting materials.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08367706B2 |
| Quelldatensatz | uspto-grants-2013_02 |
| ORD ID | ord-eac57c445eae4eb0aa53c3d2540b568c |
| Quellennotiz | uspto-grants-2013_02 |