2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[2-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2-hydroxyethyl]pyridin-2-yl}amino)thiophene-3-carboxamide

HRID 385802Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385802
Br[C:2]1[N:7]=[C:6]([CH2:8][CH:9]([CH:11]2[CH2:16][CH2:15][S:14](=[O:18])(=[O:17])[CH2:13][CH2:12]2)[OH:10])[CH:5]=[CH:4][CH:3]=1.[NH2:19][C:20]1[S:21][C:22]([C:28]2[C:33]([F:34])=[CH:32][C:31]([C:35]([OH:38])([CH3:37])[CH3:36])=[CH:30][C:29]=2[F:39])=[CH:23][C:24]=1[C:25]([NH2:27])=[O:26]>>[F:39][C:29]1[CH:30]=[C:31]([C:35]([OH:38])([CH3:37])[CH3:36])[CH:32]=[C:33]([F:34])[C:28]=1[C:22]1[S:21][C:20]([NH:19][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][CH:9]([CH:11]3[CH2:16][CH2:15][S:14](=[O:18])(=[O:17])[CH2:13][CH2:12]3)[OH:10])[N:7]=2)=[C:24]([C:25]([NH2:27])=[O:26])[CH:23]=1

Komponenten

3

Edukt 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595256372-(6-bromopyridin-2-yl)-1-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)ethanol

Produkt 1

HCID 595262155-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[2-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-2-hydroxyethyl]pyridin-2-yl}amino)thiophene-3-carboxamide

Versuchsvorschrift

The title compound was prepared according to the general procedure in Example 1 using 2-(6-bromopyridin-2-yl)-1-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)ethanol (0.11 g, 0.32 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.10 g, 0.32 mmol) as the starting materials.

Quellen und Nachweise

ORD-Eintrag
ord-b75a95c8bfe340b7a4854f89ccee5f65
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

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