HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Morpholine → Ammonia
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Morpholine | HCID 8083 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 3-(Bromomethyl)-6-chloro-2-methylpyridine | HCID 59526174 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | Ammonia | HCID 222 | — |
| Produkt | 4-[(6-Chloro-2-methylpyridin-3-yl)methyl]morpholine | HCID 51341953 | — |
Reaktionsschritte
3-(Bromomethyl)-6-chloro-2-methylpyridine (500 mg, 2.27 mmol) was taken up in CH2Cl2 (5.0 mL) and morpholine (257 μL, 2.95 mmol) and DIEA (594 μL, 3.40 mmol) were added. After stirring at room temperature overnight, the reaction was diluted with water and extracted with CH2Cl2 (2×). The combined organic layers were dried over MgSO4, filtered, and evaporated. Flash chromatography (0-10% MeOH (w/2 M NH3)/CH2Cl2) provided the title compound as a colorless oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08367706B2 |
| Quelldatensatz | uspto-grants-2013_02 |
| ORD ID | ord-d3b4e8cd363f4bcba022ccba1d4517a5 |
| Quellennotiz | uspto-grants-2013_02 |