Hydrazine → 6-Chloro-2-methylnicotinohydrazide

HRID 385965Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385965
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([CH3:11])[N:3]=1.[NH2:12][NH2:13]>C(O)C>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:12][NH2:13])=[O:7])=[C:4]([CH3:11])[N:3]=1

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 462238396-Chloro-2-methylpyridine-3-carboxylic acid

Produkt 1

HCID 595262086-Chloro-2-methylnicotinohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

6-Chloro-2-methylnicotinic acid (Example 425, Step 1) (480 mg, 2.59 mmol) was taken up in ethanol (5.2 ml). Hydrazine (0.8 ml, 12.93 mmol) was added and the reaction was heated to 80° C. overnight. It was then concentrated under reduced pressure and purified via silica gel chromatography (0-3% methanol in ethyl acetate) to yield the title compound.

Aufarbeitung

  1. concentrationIt was then concentrated under reduced pressure
  2. custompurified via silica gel chromatography (0-3% methanol in ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-a1171008c2dd4f439d6475d347bd0f01
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

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