2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-methyl-5-{[2-(3-oxomorpholin-4-yl)ethoxy]methyl}pyridin-2-yl)amino]thiophene-3-carboxamide

HRID 385982

Reaktionsgleichung

Reaktionsgleichung von HRID 385982
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Cl[C:23]1[N:28]=[C:27]([CH3:29])[C:26]([CH2:30][O:31][CH2:32][CH2:33][N:34]2[CH2:39][CH2:38][O:37][CH2:36][C:35]2=[O:40])=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:24]=[CH:25][C:26]([CH2:30][O:31][CH2:32][CH2:33][N:34]3[CH2:39][CH2:38][O:37][CH2:36][C:35]3=[O:40])=[C:27]([CH3:29])[N:28]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

Komponenten

3

Edukt 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595259664-{2-[(6-Chloro-2-methylpyridin-3-yl)methoxy]ethyl}morpholin-3-one

Produkt 1

HCID 595256515-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-[(6-methyl-5-{[2-(3-oxomorpholin-4-yl)ethoxy]methyl}pyridin-2-yl)amino]thiophene-3-carboxamide

Versuchsvorschrift

The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and 4-{2-[(6-chloro-2-methylpyridin-3-yl)methoxy]ethyl}morpholin-3-one (137 mg, 0.48 mmol) as starting materials.

Quellen und Nachweise

ORD-Eintrag
ord-d6033eb9cede4d8fb763bb092014af0d
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

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