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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 386048Erstellt: 25. Oktober 2026

2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → Methyl 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-5-carboxylate

https://huagongshe.com/reaction/386048

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525619—
EduktMethyl 1-[(6-bromopyridin-2-yl)methyl]-1H-1,2,3-triazole-5-carboxylateHCID 59525904—
ProduktMethyl 1-{[6-({3-(aminocarbonyl)-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-thienyl}amino)pyridin-2-yl]methyl}-1H-1,2,3-triazole-5-carboxylateHCID 59526199—

Reaktionsschritte

The title compound was synthesized from methyl 1-[(6-bromopyridin-2-yl)methyl]-1H-1,2,3-triazole-5-carboxylate (166 mg, 0.56 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (175 mg, 0.56 mmol) according to the general procedure in Example 1.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS08367706B2
Quelldatensatzuspto-grants-2013_02
ORD IDord-0fa2bef3b19c46d0b187c2471289570d
Quellennotizuspto-grants-2013_02