2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-hydroxy-1-methylethyl)pyridazin-3-yl]amino}thiophene-3-carboxamide

HRID 386122

Reaktionsgleichung

Reaktionsgleichung von HRID 386122
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([C:21]2[CH:26]=[CH:25][C:24]([C:27]([OH:30])([CH3:29])[CH3:28])=[CH:23][C:22]=2[F:31])=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19]>>[F:31][C:22]1[CH:23]=[C:24]([C:27]([OH:30])([CH3:28])[CH3:29])[CH:25]=[CH:26][C:21]=1[C:15]1[S:14][C:13]([NH:12][C:2]2[N:7]=[N:6][C:5]([C:8]([OH:11])([CH3:10])[CH3:9])=[CH:4][CH:3]=2)=[C:17]([C:18]([NH2:20])=[O:19])[CH:16]=1

Komponenten

3

Edukt 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595261612-(6-Chloropyridazin-3-yl)propan-2-ol2×

Produkt 1

HCID 595258595-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-hydroxy-1-methylethyl)pyridazin-3-yl]amino}thiophene-3-carboxamide

Versuchsvorschrift

The title compound was prepared by using the procedure listed in Example 1 with starting materials 2-(6-chloropyridazin-3-yl)propan-2-ol (Intermediate 45) (117 mg, 0.68 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (200 mg, 0.68 mmol).

Quellen und Nachweise

ORD-Eintrag
ord-9c87e8e43b5343138ba63c401fc048ec
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

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