Sodium Bicarbonate → HCID 178448789, Verbindung

HRID 386127Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 386127
[C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:16][C:15]([NH:17][C:18]3[CH:23]=[CH:22][N:21]=[C:20]([O:24]CC[Si](C)(C)C)[N:19]=3)=[C:14]([C:31]([NH2:33])=[O:32])[CH:13]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])#[N:2].C([O-])(O)=O.[Na+]>C(Cl)Cl.C(O)(C(F)(F)F)=O>[C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:16][C:15]([NH:17][C:18]3[CH:23]=[CH:22][NH:21][C:20](=[O:24])[N:19]=3)=[C:14]([C:31]([NH2:33])=[O:32])[CH:13]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])#[N:2]

Komponenten

5

Edukt 2

HCID 516892Sodium BicarbonateHCID 595256505-[4-(1-Cyano-1-methylethyl)phenyl]-2-({2-[2-(trimethylsilyl)ethoxy]pyrimidin-4-yl}amino)thiophene-3-carboxamide

Produkt 1

HCID 178448789HCID 178448789, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

5-[4-(1-Cyano-1-methylethyl)phenyl]-2-({2-[2-(trimethylsilyl)ethoxy]pyrimidin-4-yl}amino)thiophene-3-carboxamide (107 mg, 0.223 mmol) was stirred in a mixture of DCM (5 mL) and TFA (2 mL) at room temperature for 30 minutes. Saturated NaHCO3 was added and the resulting precipitate collected by filtration and washed with water and DCM to give the title compound as a yellow solid.

Aufarbeitung

  1. filtrationthe resulting precipitate collected by filtration
  2. washwashed with water and DCM

Quellen und Nachweise

ORD-Eintrag
ord-7a7389dbc9984a48a00cc8cce57457a0
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

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