Sodium Hydroxide → 8-(2-Methoxy-4-methylmercapto-phenyl)-purin-2,6-dione
Reaktionsgleichung
[NH2:1][C:2]1[NH:3][C:4](=[O:22])[NH:5][C:6](=[O:21])[C:7]=1[NH:8][C:9](=O)[C:10]1[CH:15]=[CH:14][C:13]([S:16][CH3:17])=[CH:12][C:11]=1[O:18][CH3:19].[OH-].[Na+]>C(O)C>[CH3:19][O:18][C:11]1[CH:12]=[C:13]([S:16][CH3:17])[CH:14]=[CH:15][C:10]=1[C:9]1[N:8]=[C:7]2[C:2](=[N:3][C:4](=[O:22])[NH:5][C:6]2=[O:21])[N:1]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Two grams of 4-amino-5-(2-methoxy-4-methylmercapto-benzoylamino)-pyrimidin-2,6-dione are refluxed for 21 hours with 50 ml of ethanol and 50 ml of 2N sodium hydroxide solution. After about 15 minutes, a solution is formed. After cooling, the solution is suction filtered with glacial acetic acid, washed with water, and dried at 70° C. in a circulating air drier. The crude product thus obtained is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (19:1, 9:1, 4:1 and ethanol)].