8-(2-Dimethylamino-4-nitro-phenyl)purin-6-one → 8-(4-Amino-2-dimethylamino-phenyl)purin-6-one

HRID 3864Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 3864
[CH3:1][N:2]([CH3:22])[C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[C:12]1[N:20]=[C:19]2[C:14](=[N:15][CH:16]=[N:17][C:18]2=[O:21])[N:13]=1.[H][H]>CO.[Ni]>[NH2:9][C:7]1[CH:6]=[CH:5][C:4]([C:12]2[N:20]=[C:19]3[C:14](=[N:15][CH:16]=[N:17][C:18]3=[O:21])[N:13]=2)=[C:3]([N:2]([CH3:22])[CH3:1])[CH:8]=1

Komponenten

5

Edukt 2

HCID 201532228-(2-Dimethylamino-4-nitro-phenyl)purin-6-oneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 201532408-(4-Amino-2-dimethylamino-phenyl)purin-6-one

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

An amount of 0.9 gm of 8-(2-dimethylamino-4-nitro-phenyl)purin-6-one is hydrogenated in 50 ml of methanol in the presence of 0.5 gm of Raney nickel at ambient temperature and under 5 bars of pressure with hydrogen for three hours until the calculated quantity has been taken up. After the catalyst has been subjected to suction filtration, the filtrate is evaporated to dryness in vacuo.

Aufarbeitung

  1. filtrationAfter the catalyst has been subjected to suction filtration
  2. customthe filtrate is evaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-7272044c980b48afb3322c501ec35ccc
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04722929

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