4-Hydroxybenzaldehyde → 3-Buten-2-one, 4-(4-hydroxyphenyl)-

HRID 38664

Reaktionsgleichung

Reaktionsgleichung von HRID 38664
[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=O)=[CH:4][CH:3]=1.[CH3:10][C:11]([CH3:13])=[O:12]>[OH-].[Na+]>[OH:1][C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[CH:10][C:11](=[O:12])[CH3:13])=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 1264-HydroxybenzaldehydeHCID 180Acetone

Produkt 1

HCID 956483-Buten-2-one, 4-(4-hydroxyphenyl)-Ausbeute 70,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel2×

Versuchsvorschrift

4-Hydroxybenzaldehyde (10 g, 82 mmol) was dissolved in 28 ml of 10% sodium hydroxide aqueous solution, then acetone (20 ml) and 10% sodium hydroxide aqueous solution (40 ml) was added under stirring, and the reaction mixture was stirred for 6 hr at room temperature. separated solid diluted with water until all separated solid dissolved. The reaction mixture was neutralized with hydrochloric acid to pH=7.0. The precipitated solid was collected by filtration and washed with water and ethanol successively. The crude product was recrystallized from ethanol to give 9.3 g of a pale yellow solid, mp: 104-105° C., yield: 70.4%.

Aufarbeitung

  1. stirringthe reaction mixture was stirred for 6 hr at room temperature
  2. customseparated solid
  3. additiondiluted with water until all separated solid
  4. dissolutiondissolved
  5. filtrationThe precipitated solid was collected by filtration
  6. washwashed with water and ethanol successively
  7. customThe crude product was recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f526c903b5bf482daf69f8cfb513b16b
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524744B2

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