HCID 59129205, Verbindung → 5-methyl-6-nitro-1H-indole
Reaktionsgleichung
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[NH:7][CH2:6][CH2:5]2>O1CCOCC1>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[NH:7][CH:6]=[CH:5]2Komponenten
3
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
5-Methyl-6-nitroindoline (0.75 gr) was dissolved in 20 mL dioxane and treated with 1.5 g of dichloro dicyano quinone. The solution was heated at 80° C. for two hours, then cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by flash chromatography to give 0.5 g of 5-methyl-6-nitroindole (e/z (M+H) 177).
Aufarbeitung
- temperaturecooled to room temperature
- filtrationfiltered
- concentrationThe filtrate was concentrated under reduced pressure
- customthe residue was purified by flash chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-e43a2c6cdfb3456ba75f1f582c0d2e14
- Quelldatensatz
- uspto-grants-2013_02
- Patentnummer
- US08372865B2
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