Methanol → HCID 57419860, Verbindung

HRID 38699Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 38699
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[F:8].S(Cl)(Cl)=O.[CH3:17]O>>[CH3:17][O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([Br:1])[CH:3]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 34163393-Bromo-4-fluorophenylacetic Acid

Produkt 1

HCID 57419860HCID 57419860, Verbindung

Versuchsvorschrift

3-Bromo-4-fluorophenylacetic acid (2.078 g, 8.92 mmol) and thionyl chloride (1.3 mL, 17.84 mmol) were combined in MeOH (20 mL) and stirred at room temperature for 10 minutes. The mixture was concentrated, and the residue was worked up with CH2Cl2 and 1N aqueous NaOH. The organic layer was dried over MgSO4, filtered, and concentrated to give the title compound.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. dry with materialThe organic layer was dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ed4b6c1e36844eacaa4bfe898d5b7ccd
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524748B2

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