Potassium Hydroxide → 8-(2-Methoxy-4-benzyloxy-phenyl)-2-benzyloxypurine

HRID 3870

Reaktionsgleichung

Reaktionsgleichung von HRID 3870
[OH-:1].[K+].[CH3:3][O:4][C:5]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:8]=[CH:7][C:6]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][C:23](Cl)=[N:24][CH:25]=2)[N:20]=1>C(O)C1C=CC=CC=1>[CH3:3][O:4][C:5]1[CH:10]=[C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:8]=[CH:7][C:6]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][C:23]([O:1][CH2:19][C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][CH:5]=3)=[N:24][CH:25]=2)[N:20]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 135323868-(2-Methoxy-4-benzyloxy-phenyl)-2-chloro-purine

Produkt 1

HCID 135323998-(2-Methoxy-4-benzyloxy-phenyl)-2-benzyloxypurine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 244Benzyl AlcoholLösungsmittel

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

An amount of 4.5 gm of powdered potassium hydroxide is dissolved in 70 ml of benzyl alcohol, and then 7.2 gm of 8-(2-methoxy-4-benzyloxy-phenyl)-2-chloro-purine are added. The mixture is heated to 150° C. for three hours, cooled, and filtered, the filtrate is mixed with ether, and the precipitate obtained is purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)].

Aufarbeitung

  1. temperaturecooled
  2. filtrationfiltered
  3. additionthe filtrate is mixed with ether
  4. customthe precipitate obtained
  5. customis purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:2.5)]

Quellen und Nachweise

ORD-Eintrag
ord-18a6059416844248a8ba411c923fd244
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04722929

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