Azetidine → 1-[(5-Bromo-2-thienyl)methyl]azetidine

HRID 387381Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 387381
[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]C2)=[CH:4][CH:3]=1.N1CCC1>>[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 10422AzetidineHCID 593327581-[(5-Bromo-2-thienyl)methyl]pyrrolidine

Produkt 1

HCID 593327501-[(5-Bromo-2-thienyl)methyl]azetidine

Versuchsvorschrift

The above procedure to make 1-[(5-bromo-2-thienyl)methyl]pyrrolidine was repeated except using azetidine (86 mg, 1.5 mmol) as the amine. Following the purification with the SCX column as described -[(5-bromo-2-thienyl)methyl]pyrrolidine an additional purification step on a 40 g ISCO silica column was necessary to afford the title compound (166 mg) of acceptable purity for use in the next reaction.

Aufarbeitung

  1. customthe purification with the SCX column
  2. customan additional purification step on a 40 g ISCO silica column

Quellen und Nachweise

ORD-Eintrag
ord-23eca20410af448b92c0fb964823589f
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08372875B2

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