1H-Benzotriazole-1-methanol → N-{1-(1H-Benzotriazolyl)methyl}-4-benzyloxy-2-fluoroaniline

HRID 388021

Reaktionsgleichung

Reaktionsgleichung von HRID 388021
[CH2:1]([O:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([F:16])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:17]1([CH2:26]O)[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1>CO>[N:17]1([CH2:26][NH:13][C:12]2[CH:14]=[CH:15][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:10][C:11]=2[F:16])[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[N:19]=[N:18]1

Komponenten

4

Edukt 2

HCID 2241691H-Benzotriazole-1-methanolHCID 114998094-(Benzyloxy)-2-fluoroaniline

Produkt 1

HCID 22936313N-{1-(1H-Benzotriazolyl)methyl}-4-benzyloxy-2-fluoroanilineAusbeute 66,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

After dissolving 4-benzyloxy-2-fluoroaniline (11.25 g, 51.78 mmol) in methanol (300 ml), 1H-benzotriazole-1-methanol (8.11 g, 54.37 mmol) was added and the mixture was stirred for 10 hours at room temperature. The precipitated crystals were filtered out, washed with ethanol and dried by aspiration to obtain the title compound (12.01 g, 34.47 mmol, 66.57%) as colorless crystals.

Aufarbeitung

  1. additionwas added
  2. filtrationThe precipitated crystals were filtered out
  3. washwashed with ethanol
  4. customdried by aspiration

Quellen und Nachweise

ORD-Eintrag
ord-cc5446e4087a46568ebdea5815b005e6
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08372981B2

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