2-Methoxypyridine-3,4-diamine → 2-(2-Methoxy-4-methoxycarbonyl-phenyl)-5H-imidazo[4,5-c]pyridin-4-one hydrochloride

HRID 3883Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 3883
C[O:2][C:3]1[C:8]([NH2:9])=[C:7]([NH2:10])[CH:6]=[CH:5][N:4]=1.CO[C:13]1[CH:21]=[C:20]([C:22]#N)[CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16].[Cl:24][CH:25](Cl)C.[CH2:28]([OH:30])C>>[ClH:24].[CH3:28][O:30][C:21]1[CH:13]=[C:14]([C:15]([O:17][CH3:25])=[O:16])[CH:18]=[CH:19][C:20]=1[C:22]1[N:9]=[C:8]2[C:3](=[O:2])[NH:4][CH2:5][CH:6]=[C:7]2[N:10]=1

Komponenten

4

Edukt 3

HCID 101489982-Methoxypyridine-3,4-diamineHCID 151660044-Cyano-2-methoxybenzoic acidHCID 18381953Dichloroethane ethanol

Produkt 1

HCID 704203902-(2-Methoxy-4-methoxycarbonyl-phenyl)-5H-imidazo[4,5-c]pyridin-4-one hydrochloride

Versuchsvorschrift

Prepared analogously to Example 1 from 2-methoxy-3,4-diaminopyridine and 2-methoxy-4-cyano-benzoic acid. The product mixture obtained is digested with dichloroethane/ethanol (3:1). The undissolved material is filtered off, and the solution is evaporated and boiled with methanolic hydrochloric acid. On cooling, the product crystallizes out in the form of the hydrate.

Aufarbeitung

  1. customThe product mixture obtained
  2. filtrationThe undissolved material is filtered off
  3. customthe solution is evaporated
  4. temperatureOn cooling
  5. customthe product crystallizes out in the form of the hydrate

Quellen und Nachweise

ORD-Eintrag
ord-1bcc2a3d16bb4766b58a295e2fc2fc6b
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04722929

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