1-Methylpiperidine-4-carbonyl chloride → 1-methylpiperidine-4-carboxylic acid (6-amino-1H-indazol-3-yl)-amide

HRID 388927

Reaktionsgleichung

Reaktionsgleichung von HRID 388927
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([C:8](Cl)=[O:9])[CH2:4][CH2:3]1.[NH2:11][C:12]1[C:20]2[C:15](=[CH:16][C:17]([NH2:21])=[CH:18][CH:19]=2)[NH:14][N:13]=1>>[NH2:21][C:17]1[CH:16]=[C:15]2[C:20]([C:12]([NH:11][C:8]([CH:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)=[O:9])=[N:13][NH:14]2)=[CH:19][CH:18]=1

Komponenten

3

Edukt 2

HCID 4365031-Methylpiperidine-4-carbonyl chlorideHCID 534153661H-Indazole-3,6-diamine

Produkt 1

HCID 684458371-methylpiperidine-4-carboxylic acid (6-amino-1H-indazol-3-yl)-amide

Versuchsvorschrift

1-Methylpiperidine-4-carbonyl chloride (1 mmol), prepared from its corresponding carboxylic acid using general procedure E, was reacted with 3,6-diaminoindazole (1 mmol) (see Example 69) employing general procedure E to yield 1-methylpiperidine-4-carboxylic acid (6-amino-1H-indazol-3-yl)-amide.

Quellen und Nachweise

ORD-Eintrag
ord-acf926547bc548c091ab3613b09fd50a
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08377983B2

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