Sodium Hydroxide → 2-(2,4-Difluorophenoxy)-2-methylpropanoic acid

HRID 389083Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 389083
[OH-].[Na+].[F:3][C:4]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:5]=1[O:6][C:7]([CH3:14])([CH3:13])[C:8]([O:10]CC)=[O:9]>CO>[F:3][C:4]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:5]=1[O:6][C:7]([CH3:14])([CH3:13])[C:8]([OH:10])=[O:9]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 1531792HCID 1531792, Verbindung

Produkt 1

HCID 15318012-(2,4-Difluorophenoxy)-2-methylpropanoic acidAusbeute 98,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

An aqueous sodium hydroxide solution (22.4 ml) was added to a solution of ethyl 2-(2,4-difluorophenoxy)-2-methylpropanoate (2.74 g) in methanol (27.4 ml) under ice cooling, followed by stirring at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, 1M hydrochloric acid was added thereto followed by extraction with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to obtain 2-(2,4-difluorophenoxy)-2-methylpropanoic acid (2.38 g) as a colorless oily product.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated under reduced pressure, 1M hydrochloric acid
  2. additionwas added
  3. extractionthereto followed by extraction with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d64fa650d73541fd8fcda35d3e81a274
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08377923B2

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