HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Pyridine → 1-Benzoyl-1-methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Pyridine | HCID 1049 | — |
| Edukt | Benzoyl chloride | HCID 7412 | — |
| Edukt | 1-Methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea | HCID 19762408 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 1-Benzoyl-1-methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea | HCID 12942344 | — |
Reaktionsschritte
1-Methyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]urea (1.4 g.) (prepared by reacting 4-amino-1-(naphth-2-ylmethyl)piperidine with methyl isocyanate) in toluene (30 cm3) was acylated using benzoyl chloride (0.92 g) in presence of pyridine (0.6 g) to give the title compound: m.p. of HCl, hemihydrate salt =164°-166° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04722930 |
| Quelldatensatz | uspto-grants-1988_02 |
| ORD ID | ord-eded3f07bc674eab884909ce377e9ea4 |
| Quellennotiz | uspto-grants-1988_02 |