5-Methoxy-2,3,3-trimethyl-3H-indole → HCID 86637540, Verbindung

HRID 389241

Reaktionsgleichung

Reaktionsgleichung von HRID 389241
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[C:6]2([CH3:14])[CH3:13].[N+:15]([C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([N+:26]([O-:28])=[O:27])[CH:25]=1)[CH2:21][I:22])([O-:17])=[O:16]>ClC1C=CC=CC=1Cl>[I-:22].[N+:15]([C:18]1[CH:19]=[C:20]([CH:23]=[C:24]([N+:26]([O-:28])=[O:27])[CH:25]=1)[CH2:21][N+:8]1[C:9]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:11][CH:10]=2)[C:6]([CH3:14])([CH3:13])[C:7]=1[CH3:12])([O-:17])=[O:16]

Komponenten

4

Edukt 2

HCID 110953925-Methoxy-2,3,3-trimethyl-3H-indoleHCID 226090731-(Iodomethyl)-3,5-dinitrobenzene

Produkt 1

HCID 86637540HCID 86637540, VerbindungAusbeute 52,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 72391,2-DichlorobenzeneLösungsmittel

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

To 5-methoxy-2,3,3-trimethyl-3H-indole (1.90 g) was added 3,5-dinitrobenzyl iodide (4.62 g) and 1,2-dichlorobenzene (10 ml). The mixture was heated at 75° C. for 3 hours, during which time an orange solid separated. The mixture was then cooled in an ice bath and the solid fraction collected by filtration; it was washed sequentially with dichlorobenzene and diethyl ether and dried under vacuum to give the product (2.62 g).

Aufarbeitung

  1. customseparated
  2. temperatureThe mixture was then cooled in an ice bath
  3. filtrationthe solid fraction collected by filtration
  4. washit was washed sequentially with dichlorobenzene and diethyl ether
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-586ad7d3615349a1a9ad3d8ba7246df2
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08378120B2

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