2,2-diethoxy-1-(5-(2-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl)-2-thioxo-1,3-dithiol-4-yl)ethanone → 4-(Diethoxymethyl)-4-hydroxy-6,6-dimethyl-4,6-dihydro-[1,3]dithiolo[4,5-c]furan-2-thione

HRID 389292Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 389292
[CH2:1]([O:3][CH:4]([O:23][CH2:24][CH3:25])[C:5]([C:7]1[S:8][C:9](=[S:22])[S:10][C:11]=1[C:12]([O:15]C1CCCCO1)([CH3:14])[CH3:13])=[O:6])[CH3:2]>C(Cl)Cl>[CH2:1]([O:3][CH:4]([O:23][CH2:24][CH3:25])[C:5]1([OH:6])[O:15][C:12]([CH3:14])([CH3:13])[C:11]2[S:10][C:9](=[S:22])[S:8][C:7]1=2)[CH3:2]

Komponenten

3

Edukt 1

HCID 866713752,2-diethoxy-1-(5-(2-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl)-2-thioxo-1,3-dithiol-4-yl)ethanone

Produkt 1

HCID 866713764-(Diethoxymethyl)-4-hydroxy-6,6-dimethyl-4,6-dihydro-[1,3]dithiolo[4,5-c]furan-2-thione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

10 mg (0.024 mmol) of 2,2-diethoxy-1-(5-(2-(tetrahydro-2H-pyran-2-yloxy)propan-2-yl)-2-thioxo-1,3-dithiol-4-yl)ethanone 5 was dissolved in 5 mL of CH2Cl2 containing 0.1 mL CF3COOH. The reaction mixture was stirred for 12 hours, washed with 20 mL of saturated solution of NaHCO3 and, the organic layer was separated and dried in vacuum to yield the target compound 4 as a solid material. Yield: 7.2 mg (0.02 mmol, 90%).

Aufarbeitung

  1. washwashed with 20 mL of saturated solution of NaHCO3
  2. customthe organic layer was separated
  3. customdried in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-6673f3f81b574d249eb60b8da275461d
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08378123B2

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